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are given to individuals with disregard for the
homeopathic premise of ‘symptom-based
individualization’ (nosodes, for example), the study
“A systematic review of the quality of homeopathic
pathogenetic trials (HTPs) published from 1945 to
1995” [33] showed that “156 HPTs on 143
medicines, involving 2,815 volunteers, produced
20,538 pathogenetic effects (median 6.5 per
volunteer)” and called the attention to the high
frequency of occurrence of “morbid symptoms”
caused by potentized substances, “on average about
84% of volunteers receiving active treatment
developed symptoms”.
Several examples of such ‘iatrogenic events’
(‘pathogenetic symptoms’ or ‘morbid symptoms’),
which might serve as a warning against the potential
danger implicit in Golden’s “preventative program”,
are described in the materia medica of nosodes, as
e.g., in “an involuntary proving of the
Diphtherinum”, which was administered to a girl for
preventive purposes [34]. Based on the homeopathic
epistemological model, one might predict that the
same might be the case with other nosodes or any
other homeopathic remedy not prescribed as a
function of ‘symptom-based individualization’, their
pathogenetic symptoms and the patient’s individual
pattern of susceptibility (idiosyncrasy).
“A girl nine years of age having been exposed,
Nov. 13, to malignant diphtheria received
Diphtherinum 1M (Skinner) three times daily for
eleven days, as a prophylactic, developing chilliness,
high temperature, red face. She complained of being
tired and cold, severe pain on swallowing and on the
12th day the tonsils and posterior walls of the
pharynx were covered with dirty gray, yellowish
membrane, corrugated vertically, like the surface of
a wash-board turned up. Thursday, Nov. 14, 1907,
began powders, three each day for eight days, then
two daily for two days. Nov. 23, complained of being
tired, sat down to rest three times. Nov. 24, would lie
down because tired, but after a while felt playful.
Nov. 25, temperature 103, pulse 148, full, with
throbbing of carotids, eyes bright, face flushed, with
center of cheeks almost purple. Throat dark red, no
membrane; but on posterior wall of throat, yellow,
dirty cream color with dry membrane in folds, up and
down. Monday night talks in sleep, with eyes wide
open. Wanted imaginary objects taken from room,
and to “make those people get away.” Sat up and
picked among bed-clothes for strap for her school
books. Nov. 26, temperature 101.2, pulse 116,
membrane lighter and moist, thin in middle of throat.
Nov. 27, temperature 99.2, pulse 100. Throat
clearing from middle. Jerking of single limb, or
shoulder, or finger. Nov. 28, temperature 101.2,
pulse 116. Desired to have mother hold her hand.
Tongue whitish, with exceedingly red tip (moist).
Nov. 29, temperature 101.2, pulse 116, breath
offensive. Nov. 30, temperature 99.4, pulse 100.
Membrane white, and showing more to front.
Clearing from center of posterior wall of throat.
Tongue coated whitish, with red papillae; very red
tip, with a dark red spot in center of red tip. Slept
well last night, until 4 A. M., then was restless and
wakeful; moved and changed position, moved arms
and legs often, snored and fan-like motion of ala
nasi. Skin seemed dry, forehead moist along edge of
hair, when first falling asleep.” (The materia medica
of the nosodes with provings of the x-ray,
“Diphtherinum: an involuntary proving”) [34]
Any discussion of the accuracy of Golden’s
findings demands proper analysis of the presence of
“systematic error” or “bias” in the methods he
employed [29], which even without such analysis are
patently poor, as they exhibit many flaws relative to
clinical epidemiology criteria, and the conclusions
are inferred from insufficient data. For those reasons,
Golden’s results are scientifically questionable
relative to both main requirements, to wit, “safety”
(underestimation of adverse events) and “efficacy”
(overestimation of effectiveness).
“A more detailed summary of my findings is
shown in Table 2. The data is based on questionnaire
responses from parents whose children used my HP
program. Each response covered one year of a
child’s life. Some parents returned questionnaires
over 6 years, and some only for the first year of the
program. Fifteen data groups were divided into three
groups of five, based on slight differences in the HP
programs used. The third group (Series 11-15) was
studied in greater detail in order to validate the
findings of the earlier Series. Seven different tests
were performed on Series 11-15 data.” [29]
According to The Cochrane Collaboration [35],
“a bias is a systematic error, or deviation from the
truth, in results or inferences. Biases can operate in
either direction: different biases can lead to
underestimation or overestimation of the true
intervention effect. Biases can vary in magnitude:
some are small (and trivial compared with the
observed effect) and some are substantial (so that an
apparent finding may be entirely due to bias). Even
a particular source of bias may vary in direction: bias
due to a particular design flaw (e.g. lack of allocation
concealment) may lead to underestimation of an
effect in one study but overestimation in another
study. It is usually impossible to know to what extent
biases have affected the results of a particular study,